Pharmaceutical Formulation Scientist


9th December 2020

Job Description

Midatech Pharma, a leading, clinical-stage drug delivery company, is developing novel ultra-long-acting therapeutics. Building on the pioneering Q-Sphera™ technology, Midatech Pharma is developing solutions to meet the complex needs of modern, small molecule and biologic-based drug products. We are seeking a Formulation Scientist to play a key role in the research and development of these novel formulations and technologies. The successful candidate will join a highly motivated team of scientists in formulating and developing new biopharmaceutical drug candidates. Bringing energy, strong initiative and a problem-solving mindset the ideal candidate will have experience of formulating large molecule APIs and familiar with handling and characterizing protein-based formulations.

Job Summary

The candidate will be required to work with a variety of compounds, ranging from synthetic polymers to recombinant proteins and peptides. The role will comprise a mixture of in-house and client projects and provides the opportunity to work with pioneering therapies and new treatment modalities. Focussing on the study, formulation and development of novel long-acting, injectable biopharmaceuticals, the role will need to be creative and able to work well with other functions. Working across a mixture of early stage formulation discovery projects, interpreting Quality Target Product Profiles, the role is required to apply robust and innovative scientific approaches to development of novel parenteral formulations.
An understanding of polymer and protein chemistry and compounding is required along with an understanding of drug development pathways. Experience of parenteral drug formulation and large molecule therapeutics is highly desirable. Excellence in communication, teamwork and time-management are pre-requisites for this position. Familiarity with ICH guidelines and early-stage pharmaceutical development are desirable.

Specific Responsbilities

  1. Design and execution of pre-formulation studies for protein and small molecule APIs
  2. Oversee set-up & performance of new bioassays to characterise structure & activity of protein-based biopharmaceuticals
  3. Design and development of long-acting polymer-based formulations of biologics that exploit the unique benefits of the Q-Sphera production process
  4. Contribute towards proprietary process innovation and development
  5. Interpretation of target specifications and preparation of formulation development strategies
  6. Provide clear and frequent interpretation and communication of results (to include client-facing activities)

General Responsibilities

  1. Maintain high standards of laboratory practice
  2. Comply with Company Health & Safety policies
  3. Report writing and preparation of batch record documentation
  4. Perform health and safety and risk assessments
  5. Aid growth of in-house formulation capabilities
  6. Attend conferences and training events when requested
  7. Partake in lab presentations and actively participate in meetings and communicate cross-functionally internally and externally

Job Factors

Minimum education level BSc in Pharmacology, Pharmaceutical Sciences, or other related subject. PhD desirable but not essential.
Industrial experience The candidate is required to have a background in preparation, manipulation and characterisation of pharmaceutical formulations and a good understanding of relevant analytical techniques. They will be experienced in handling and formulating large molecules.
Supervision received by the role The successful candidate will work as part of a multidisciplinary team, and report directly to Pharmaceutical Formulation Team Leader. Regular performance reviews will be held but after initial orientation it is expected that the candidate will perform duties in a very self-sufficient fashion.
Supervisory responsibility There are no initial requirements for the position to supervise other scientists at this time, however as the function grows it is anticipated that this will be required.

Job Title

Pharmaceutical Formulation Scientist

Salary

Commensurate with experience

Reports To

Pharmaceutical Formulation and Development Team Leader

Location

Cardiff, Wales but may require occasional travel as required

How to Apply

To apply for any vacancies listed please submit your CV and a cover letter to: careers@midatechpharma.com